Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes. Colhoun hm1, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, thomason mj, mackness mi, charltonmenys v, fuller jh. The safety and tolerability of atorvastatin 10 mg in the collaborative. An analysis from the collaborative atorvastatin diabetes study cards author links open overlay panel helen m. Atorvastatin reduced cv events even in low ldl dm patients. An overview of cards collaborative atorvastatin diabetes study primary prevention of cardiovascular disease with atorvastatin in type 2. Atorvastatin calcium tablet is an inhibitor of hmgcoa reductase statin indicated as an adjunct therapy to diet to.
Pdf design of the collaborative atorvastatin diabetes study. The association of on study lowdensity lipoprotein ldl cholesterol and cv events by gender was evaluated in the combined studies and the impact of gender on adverse events in each study separately. The primary objective is to investigate whether treatment with the hydroxymethylglutaryl coenzyme a reductase inhibitor. Therefore, the first aim of this article is to report the effect of atorvastatin on albuminuria and estimated gfr gfr in one of the largest randomized trials n 2,838 of statin therapy in people with diabetes. The collaborative atorvastatin diabetes study cards. Jun 22, 2009 effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes. Effect of atorvastatin on glycaemia progression in patients.
An analysis from the collaborative atorvastatin diabetes study cards previous article solutesolver. In the collaborative atorvastatin diabetes study cards, the effect of lipitor on cardiovascular disease cvd endpoints was assessed in 2838 subjects 94% white, 68% male, ages 4075 with type 2 diabetes based on who criteria, without prior history of cardiovascular disease and with ldl. Ofthe collaborative atorvastatin diabetes study cards inthe belgian population marbaix s1,vandenberghe h1,van gaal l2 1p. Cost effectiveness of atorvastatin in patients with type 2. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary prevention of cardiovascular disease in patients with. The percentages of patients experiencing treatment associated adverse events.
Effects of atorvastatin on kidney outcomes and cardiovascular. Nct00327418 has been described in detail previously. Ironically, there is a very compelling clinical trial showing the value of one statin, lipitor atorvastatin, in type 2 diabetes the collaborative atorvastatin diabetes study known as cards. For the prevention of cardiovascular disease, statins are a firstline treatment.
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Lipitor atorvastatin calcium clinical studies pfizer. Methods the study population comprised 2,739 people taking part in the collaborative atorvastatin diabetes study cards who were randomised to receive atorvastatin. Analysis of efficacy and safety in patients aged 65. The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the collaborative atorvastatin diabetes study cards and followed for 3.
Read stroke prediction and stroke prevention with atorvastatin in the collaborative atorvastatin diabetes study cards, diabetic medicine on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The collaborative atorvastatin diabetes study cards is a multi. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Pdf there are few data on the role of lipid lowering in the primary prevention of coronary heart disease chd in diabetic. Stroke prediction and stroke prevention with atorvastatin. Collaborative atorvastatin diabetes study cards and fol lowed for 3. External validation of the model was performed in data from the antihypertensive and lipidlowering treatment to prevent heart attack trial allhatllt. Dec 01, 2007 read stroke prediction and stroke prevention with atorvastatin in the collaborative atorvastatin diabetes study cards, diabetic medicine on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The role of statins in diabetes treatment diabetes spectrum. The collaborative atorvastatin diabetes study cards randomized placebo controlled trial. Although the study was not powered for a direct comparison between the two statins, results of both planet i and ii suggest that atorvastatin and rosuvastatin have different renal profiles in patients with proteinuria, whereas the effects on lipids are similar, with a larger effect of rosuvastatin 40 mg than of atorvastatin 80 mg.
These guidelines are based on numerous trials showing a benefit for statin therapy both as primary and secondary prevention of cardiovascular disease and mortality 27. Rapid emergence of effect of atorvastatin on cardiovascular. Impact of female sex on lipid lowering, clinical outcomes. We aimed to identify adultonset autoimmune diabetes in patients with established type 2 diabetes participating in the collaborative atorvastatin diabetes study cards to characterize their phenotype and clinical. Major cv events occurred in 3,083 of 30,000 men 10. Based on the clinical cards data, the favourable cost effectiveness of atorvastatin 10mg in. Atorvastatin reduced major cardiovascular disease events in type 2. Primary prevention of cardiovascular disease with atorvastatin in. Data are now available from various primary prevention studies allhatllt antihypertensive and lipidlowering treatment to prevent heart attack, lipidlowering therapy, ascotlla angloscandinavian cardiac outcomes trial, lipidlowering arm, cards collaborative atorvastatin diabetes study, woscops west of scotland coronary prevention. Safety of atorvastatin in the collaborative atorvastatin diabetes study cards the safety and efficacy of sta the safety and efficacy of statins for cvd prevention is well established, yet some physicians have concerns about the longterm safety of this class.
No justification is available for having a particular threshold level of ldlcholesterol as the sole arbiter of which patients with type 2 diabetes should receive statins. Stroke prediction and stroke prevention with atorvastatin in. The study received ethical approval both centrally and at each participating institution, and each patient gave written. The association of onstudy lowdensity lipoprotein ldl cholesterol and cv events by gender was evaluated in the combined studies and the impact of gender on adverse events in each study separately.
To estimate the costeffectiveness of atorvastatin 10 mg compared with no treatment for the primary prevention of. Collaborative atorvastatin diabetes study american. Pdf primary prevention of cardiovascular disease with. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only. Collaborative atorvastatin diabetes study american college. The safety and tolerability of atorvastatin 10 mg in the.
The collaborative atorvastatin diabetes study cards 1 was a stunningly positive demonstration of the clinical benefit of statin therapy in patients with type 2 diabetes. The aim of the collaborative atorvastatin diabetes study cards was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. Renal effects of atorvastatin and rosuvastatin in patients. A webbased tool for modeling urea kinetics for a broad range of hemodialysis schedules in multiple patients. In brief, cards was a multicentre, randomised, placebocontrolled trial in 2,838 patients with type 2 diabetes aged 4075 years carried out in 2 centres in the uk and ireland. An overview of cards collaborative atorvastatin diabetes.
Effect of atorvastatin on glycaemia progression in. Pdf baseline characteristics in the collaborative atorvastatin. Mar 05, 2012 ironically, there is a very compelling clinical trial showing the value of one statin, lipitor atorvastatin, in type 2 diabetes the collaborative atorvastatin diabetes study known as cards. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes cards overview 1 a multicenter randomized placebo controlled trial to determine hard outcomes of atorvastatin 10mg vs. An overview of cards collaborative atorvastatin diabetes study. Apolipoproteins, cardiovascular risk and statin response in type 2 diabetes. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study cards. The study population comprised 2,739 people taking part in the collaborative atorvastatin diabetes study cards who were randomised to receive atorvastatin 10 mg or.
Development and validation of a model to predict absolute. Reduce the risk of mi, stroke, revascularization procedures, and angina in patients without chd, but with multiple risk factors reduce the risk of mi and stroke in patients with type 2 diabetes without chd, but with multiple risk factors. We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 6575 years at randomization with 1,709 younger patients in the collaborative atorvastatin diabetes study cards. Jun 07, 2019 atorvastatin calcium tablet is an inhibitor of hmgcoa reductase statin indicated as an adjunct therapy to diet to. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only average or below average cholesterol levels. Trials like the collaborative atorvastatin diabetes study cards, proved beyond doubt that patients with type 2 diabetes and other risk factors for cvd should be treated with a statin, apparently disregarding their initial. Effect of atorvastatin on glycaemia progression in patients with diabetes. Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus colhoun hm, betteridge dj, durrington pn, et al. Atorvastatin 10 mg daily is safe and efficacious in reducing the risk of first cardiovascular disease events, including stroke, in patients with type 2 diabetes without high ldlcholesterol. Atorvastatin reduced major cardiovascular disease events. Patients with type 2 diabetes mellitus have a high risk of developing cardiovascular cv disease. The collaborative atorvastatin diabetes study cards was a randomised, placebocontrolled trial comparing. Among these studies 1422 are the heart protection study hps, 14 the collaborative atorvastatin diabetes study ca r ds, 15 the angloscandinavian cardiac outcomes lipid lowering arm ascotlla, 16 the antihypertensive and lipid lowering treatment to prevent heart attack allhat study, 17 and the management of elevated cholesterol in the. Atorvastatin reduced major cardiovascular disease events in.
The goal of the collaborative atorvastatin diabetes study cards trial was to determine the effectiveness of the lipidlowering agent atorvastatin in reducing cardiovascular events and death among diabetic patients with at least one heart disease risk factor, but without elevated cholesterol. Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the collaborative atorvastatin diabetes study cards diabetologia, dec 2005 h. Objective diabetesassociated autoantibodies can be detected in adultonset diabetes, even when initially noninsulin requiring, i. In their analysis of the outcomes from cards, based on linear analysis, they determine the value of apolipoprotein b apob that corresponds to target values of ldl.
Atorvastatin, sold under the brand name lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. We examined the relationship of srage and esrage to incident coronary heart disease chd and stroke in type 2 diabetic patients followed for 3. Collaborative atorvastatin diabetes study listed as cards. Mar 01, 2009 the collaborative atorvastatin diabetes study cards 1 was a stunningly positive demonstration of the clinical benefit of statin therapy in patients with type 2 diabetes. Reduce the risk of mi, stroke, revascularization procedures, and angina in patients without chd, but with multiple risk factors. Safety of atorvastatin in the collaborative atorvastatin. In the collaborative atorvastatin diabetes study cards, the effect of atorvastatin calcium on cardiovascular disease cvd endpoints was assessed in 2838 subjects 94% white, 68% male, ages 40 to 75 with type 2 diabetes based on who criteria, without prior history of cardiovascular disease and with ldl. Openurl1crossref2pubmed3web of science4 q in patients with type 2 diabetes mellitus, is atorvastatin better than. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of pre.
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study. Atorvastatin in patients with type 2 diabetes mellitus. The collaborative atorvastatin diabetes study cards was a doubleblind, randomized, placebocontrolled, multicenter trial of atorvastatin 10 mgday for the primary prevention of cvd in type 2 diabetes. Dec 17, 2008 apolipoproteins, cardiovascular risk and statin response in type 2 diabetes. American diabetes association indications for statins in. The clinical benefit of use of statins in patients with type 2 diabetes has been demonstrated in several randomized, controlled trials, including the cards clinical trial. An analysis from the collaborative atorvastatin diabetes study cards. Methods the collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebo. Design of the collaborative atorvastatin diabetes study. To describe baseline characteristics of patients in the collaborative atorvastatin diabetes study cards, a randomized. Jun 22, 2009 therefore, the first aim of this article is to report the effect of atorvastatin on albuminuria and estimated gfr gfr in one of the largest randomized trials n 2,838 of statin therapy in people with diabetes.
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